Identifying Novel Protein Partners for DUBTACs to Expand the Viable Targets for Stabilization & Restoring Protein Function in New Disease Paradigms
Time: 1:05 pm
day: Pre-Conference Day
Details:
DUBTACs present a vastly developing paradigm of induced proximity modalities with therapeutic utility for disorders linked to perturbed ubiquitin signaling, such as oncology and neurodegenerative conditions. Despite offering a novel avenue to modulate ubiquitin homeostasis beyond degradation, clinically relevant targets have yet to gain proof of concept. Attaining selective DUB and E3 ligase pairs confronts redundancies within the ubiquitin system and knowledge gaps in the repertoire of structurally distinct DUBs utilized. Hijacking a broader range of highly cooperative DUB-E3 ligase pairs is pivotal to unlocking the complete therapeutic potential of DUBTACs and broadening their application in precision medicine.
This workshop will discuss:
- How to systematically profile novel ligands for DUB recruitment?
- How to expand the repertoire of targeted DUBs?
- What targets are most benefited by DUBTACs?
- How to predict and validate if stabilizing the target confers functional benefit?
- What are the key design principles for DUBTACs?
