Leveraging Neo-Native E3 Ligases for Screening to Expand Induced Proximity Drug Discovery
Time: 12:00 pm
day: Day One
Details:
- How to develop E3 ligase-agnostic screening strategies, like covalent ligand discovery and electrophilic fragment libraries, to uncover novel ligase-substrate pairs and expand the scope of induced proximity drug discovery?
- How to leverage functional proteomics, RNA-seq, and single-cell profiling to map tissuespecific E3 ligase expression patterns and design next-gen proximity inducers with improved selectivity?
- How to harness insights from chemical proteomics and AI driven modeling to accelerate discovery of non-degradative E3 ligases that modulate protein function via PTMs beyond degradation?