8:00 am Registration & Networking

8:50 am Chair’s Opening Remarks

On the Origins of Induced-Proximity for Therapy: The Road to Rational Discovery

9:00 am Panel Discussion: Advancing the Discovery of Proximity-Based Medicines

Synopsis

  • What needs to be done to make induced proximity a realistic therapeutic modality?
  • What are the key challenges holding back the progress of the field?
  • What are the most promising compounds in development?

10:00 am 30 Years of Molecular Glues: Controlling Cell Circuitry in Biology and Medicine

Synopsis

  • Details to be revealed

10:30 am Virtual Speed Networking

Synopsis

Grab a quick cup of tea or coffee from the comfort of your own kitchen and jump straight into your opportunity to connect with new contacts from active companies in the field and exchange digital business cards. Network and form lasting connections through this exclusive virtual speed networking!

11:30 am Chemically Induced Proximity in Biology and Medicine

  • Benjamin Stanton Principal Investigator, Abigail Wexner Research Institute at Nationwide Children’s Hospital

Synopsis

  • Overview of induced proximity: for which biologic processes is proximity sufficient?
  • Overview of induced proximity for gene regulation, signal transduction, protein degradation
  • Induced proximity and chromatin sequencing: how are we normalizing our data for global effects?

11:55 am Induced Proximity: An Investors Perspective

Synopsis

  • Current Trends
  • A Investors view of the landscape
  • Forecasting future trends

12:20 pm Live Presenter Q&A

  • Benjamin Stanton Principal Investigator, Abigail Wexner Research Institute at Nationwide Children’s Hospital
  • Jamie Kasuboski Vice President, OMX Ventures

Synopsis

  • Ask the speakers your most burning questions!

12:40 pm Networking Lunch

Uncovering Key Technologies to Drive the Field Forward

1:40 pm Strategies to Discover Molecular Glue Degraders at Scale

Synopsis

  • Molecular glue degraders have astonishing pharmacological properties
  • Their discovery had been entirely driven by serendipity
  • Differential chemical profiling using hyponeddylated models allowed us to identify novel molecular glues at scale

2:05 pm Scalable Discovery and Streamlined Characterization of Novel Molecular Glue Degraders

Synopsis

  • The Proxygen discovery platform enables rational screening for molecular glue degraders on an industrial scale
  • Ligase-agnostic glue degrader screening is achieved through integration of cellular assays with functional genomics and proteomics
  • Here we present a case study on the discovery, characterization and chemical optimization of a novel molecular glue degrader

2:30 pm Live Presenter Q&A

Synopsis

  • Ask the speakers your most burning questions!

2:50 pm Afternoon Break

3:30 pm Reimagining Druggability using Chemoproteomic Platforms

  • Daniel Nomura Professor of Chemical Biology, University of California, Berkeley

Synopsis

  • Using chemoproteomics to tackle undruggable targets
  • Using chemoproteomic to expand the scope of targeted protein degradation
  • Using chemoproteomics to develop new induced proximity-based therapeutic modalities

3:55 pm Chemoproteomic Approaches to Interrogate the Degradable Kinome

  • Fleur Ferguson Assistant Professor, University of California, San Diego

Synopsis

  • An experimental map of the degradable kinome reveals chemical leads for > 200 kinases
  • The effects of chemical and cellular variables on proximity-mediated degradation outcomes are examined across the kinome
  • Multi-targeted probes are used to uncover the role of p97 in kinase degradation

4:20 pm Live Presenter Q&A

  • Daniel Nomura Professor of Chemical Biology, University of California, Berkeley
  • Fleur Ferguson Assistant Professor, University of California, San Diego

Synopsis

  • Ask the speakers your most burning questions!

4:45 pm Closing Remarks & End of Conference Day One