Jonathan Solomon

Jonathan Solomon

Company: Novartis Institutes for Biomedical Research

Job title: Associate Director

Seminars:

Discovery of a VHL-binding Molecular Glue Degrader 11:25 am

Protein arrays were used to screen for novel compound-induced interactions between the VHL E3 ligase and thousands of proteins A small molecule was identified that recruits the VHL E3 ligase to cysteine dioxygenase (CDO1) resulting in proteasome-dependent degradation of CDO1 The ternary complex X-ray structure shows the VHL-binding molecule acts as a molecular glue by…Read more

day: Day Two

Live Presenter Q&A 11:50 am

Ask the speakers your most burning questions!Read more

day: Day Two

© Copyright 2018 Hanson Wade | Design and site by Event Engine | Hanson Wade Limited is registered in England & Wales, number 06752216.
Registered Office: Suite A, 6 Honduras Street, London EC1Y 0TH.