Tumor-Targeted Protein Degradation Mediated by Cellular Chaperones

Time: 3:45 pm
day: Day One


  • Chaperones can direct not only the correct folding of proteins, but also their degradation via the ubiquitin-proteasome system
  • Chemically inducing proximity between a drug target and the cellular chaperone machinery results in its degradation, which is mediated by the numerous E3 ligases associated with chaperone complexes
  • Chaperone-mediated protein degradation (CHAMP™) has a number of advantages, including an improved safety margin due to selective drug accumulation in tumor tissues