Targeted Degradation of Extracellular Proteins Using Antibody-Based Biologics

Time: 4:45 pm
day: Day One


  • Targeted protein degradation is an established new modality for drug discovery for intracellular proteins, yet most small molecule and biologics engage extracellular targets
  • We have recently shown it possible to degrade therapeutically relevant membrane proteins by recruiting transmembrane E3 ligases to proteins of interest using bi-specific antibodies, a biologics technology akin to small molecule PROTACs, we call AbTACs (Cotton et al. JACS 2021)
  • This talk will describe recent optimization and expansion of this modality for degrading surface proteins