Presenting Protein Rescue Targeting Chimeras (PRESTACs) for Targeted Protein Stabilization

Time: 9:00 am
day: Conference Day Two


  • Leveraging the targeted stabilization of therapeutically relevant proteins which can be achieved by recruiting Deubiquitinases (DUBs) to deubiquitinate target proteins and prevent their degradation
  • Exploring how heterobifunctional molecules, called Protein Rescue Targeting Chimeras (PRESTACs), can be generated by chemically linking a DUB ligand to a target protein ligand
  • Understanding how Progenra has discovered and characterized novel small molecule DUB ligands which are used to design and synthesize PRESTACs to stabilize disease-relevant targets
  • Learning strategies for discovering and characterizing novel DUB ligands using Progenra’s UbiProTM platform will be discussed