Panel Discussion: Advancing the Discovery & Development of Induced Proximity Molecules

Time: 11:30 am
day: Day One


  • How to optimize the drug like properties of induced proximity molecules
  • Understanding and overcoming PKPD challenges
  • What ADME properties are desirable and how does this differ between targets?
  • What should the pharmaceutical profile look like?
  • Covalent interactions vs non-covalent interactions
  • Proximity is target and enzyme dependent so what is the best way of going about the rational discovery and design?
  • Is it best to use purified proteins and enzymes or is it more efficient to do it in cells first and then optimize?
  • Expanding therapies beyond oncology