Creating Small Molecule Stabilizers of the 14-3-3 Phosphoprotein Regulators & Their Disease-Driving Client Proteins

Time: 4:00 pm
day: Day Two


  • The 14-3-3 family of adaptor proteins regulate thousands of phosphoprotein clients, many of which play critical roles in diseases of unmet medical need
  • The identification of molecular glues stabilizing protein-protein interactions is facilitated by a detailed structural, biochemical and biophysical understanding of the interaction
  • Ambagon Therapeutics is a leader in developing a modular approach to molecular glue discovery, utilizing a significant data set of the interactions between 14-3-3 adaptor proteins and their phosphoprotein clients